Table 3.

Viable counts and endotoxin release for ESBL-producing E. coli isolate over a 3 h exposure period to ceftazidime and phendione at the concentrations of 2× MIC, 10× MIC and 100× MIC.

	Treatment	Viable Count (cfu/mL)	Log10 Reduction in Viable Count	Endotoxin Release (EU/mL)	Endotoxin/cfu (EU/cfu)
0 h	Control	2.7 × 107		9454	3.5 × 10−4
1.5 h	Control	3.6 × 108		22,962	6.4 × 10−5
	2× MIC ceftazidime	3.0 × 106	2.1	23,729	7.9 × 10−3
	10× MIC ceftazidime	4.0 × 105	3.0	34,797	8.7 × 10−2
	100× MIC ceftazidime	2.9 × 103	5.1	34,112	1.2× 101
	2× MIC phendione	3.9 × 107	1.0	39,012	1.0 × 10−3
	10× MIC phendione	2.9 × 103	5.1	12,300	4.3 × 100
3 h	Control	9.0 × 108		24,700	2.7 × 10−5
	2× MIC ceftazidime	9.0 × 105	3.0	18,824	2.1 × 10−2
	10× MIC ceftazidime	1.0 × 105	4.0	35,820	3.6 × 101
	100× MIC ceftazidime	5.5 × 101	7.2	21,122	3.84 × 102
	2× MIC phendione	2.4 × 107	1.6	20,506	8.5 × 10−4
	10× MIC phendione	1.5 × 102	6.8	10,300	6.9 × 101

2× MIC ceftazidime = 2 µg/mL; 10× MIC ceftazidime = 10 µg/mL; 100× MIC ceftazidime = 100 µg/mL; 2× MIC phendione = 12.5 µg/mL; 10× MIC phendione = 62.5 µg/mL.