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. 2021 Oct 29;10(11):1731. doi: 10.3390/antiox10111731

Table 3.

Subgroup analyses of green tea supplementation on oxidative stress biomarkers.

NO WMD (95%CI) p P Heterogeneity I2
Subgroup analyses of green tea supplementation on TAC concentrations.
Overall effect 16 0.20 (0.09, 0.30) <0.001 <0.001 98.6%
Trial duration (week)
<8 5 0.43 (0.10, 0.75) 0.010 <0.001 99.6%
≥8 11 0.08 (0.02, 0.13) 0.004 <0.001 80.1%
Type of green tea
Green tea extract 12 0.23 (0.03, 0.42) 0.019 <0.001 98.9%
Brewed green tea 4 0.07 (0.03, 0.10)_ <0.001 0.169 40.5%
Sex
Both 8 0.12 (0.08, 0.17) <0.001 0.173 32.0%
Male 6 0.38 (0.07, 0.69) 0.003 <0.001 99.5%
Female 1 0.05 (0.04, 0.05) 0.015 - -
Intervention dose (mg/d)
≤400 6 0.06 (−0.01, 0.13) 0.132 <0.001 87.1%
>400 10 0.29 (0.09, 0.49) 0.004 <0.001 99.1%
Health status
Healthy 11 0.08 (0.02, 0.13) 0.004 <0.001 80.1%
Unhealthy 5 0.43 (0.10, 0.75) 0.010 <0.001 99.6%
Baseline BMI (kg/m2)
18.5–24.9 6 0.38 (0.08, 0.68) 0.011 <0.001 99.5%
25–29.9 4 0.11 (0.07, 0.15) <0.001 0.387 1.1%
≥30 5 0.06 (−0.03, 0.16) 0.176 <0.001 88.2%
Subgroup analyses of green tea supplementation on MDA concentrations
Overall effect 8 −0.00 (−0.00, 0.00) 0.636 <0.001 84.1%
Trial duration (week)
<8 3 −0.08 (−0.21, 0.04) 0.185 0.002 84.2%
≥8 5 −0.00 (−0.00, 0.00) 0.860 <0.001 86.3%
Type of green tea
Green tea extract 4 −0.17 (−0.43, 0.09) 0.202 0.004 77.1%
Brewed green tea 4 −0.00 (−0.00, 0.00) 0.860 <0.001 89.5%
Sex
Both 4 −0.00 (−0.00, 0.00) 0.860 <0.001 89.5%
Male 3 −0.18 (−0.51, 0.15) 0.499 0.002 84.3%
Intervention dose
≤400 2 −0.01 (−0.02, 0.00) 0.215 0.530 0.0%
>400 6 −0.00 (−0.00, 0.00) 0.821 <0.001 88.1%
Health status
Healthy 6 −0.00 (−0.00, 0.00) 0.853 <0.001 82.9%
Unhealthy 2 −0.20 (−0.61, 0.20) 0.331 <0.001 92.1%
BMI
18.5–24.9 3 −0.46 (−0.98, 0.05) 0.081 <0.001 95.0%
25–29.9 3 −0.00 (−0.00, 0.00) 0.493 0.609 0.0%
≥30 2 −0.12 (−0.45, 0.20) 0.451 0.910 0.0%

Abbreviations: CI, confidence interval; WMD, weighted mean differences.