Figure 1.

Selection of the preliminary sets of blood AD- and CVD-related genes. First, DEGs between different disease status (e.g., disease and healthy control) were selected using limma [19], following which the domain knowledge obtained from the disease–gene relationship databases was implemented to select the disease-related genes. DEG, differentially expressed gene; Cn, control; Dx, disease; PPI, protein–protein interaction; TF, transcription factor; eQTL, expression quantitative trait loci; GWAS, genome-wide association study.