Table 4.
Effects of resveratrol in combination with other compounds.
| Combination | Cell Lines | Effect | Mechanisms | Reference |
|---|---|---|---|---|
| Resveratrol + acetyl-resveratrol | SKOV-3 | Inhibited cell growth | ↓VEGF; ↓NF-κB; ↑IL-8 | [126] |
| Resveratrol + I3C | SKOV-3 | Resulted in cell cycle arrest; increased apoptosis | ↑tumor suppressor protein p21; ↓Rb; ↓SVV | [127] |
| Resveratrol + nutlin-3 +TGF-β | A2780/CP70 | Induced apoptosis | ↑caspase-3; ↑caspase-9; ↑cytochrome c | [128] |
| Resveratrol + LH3 | A2780, A2780 cisR and A2780 ZD0473R | Reduced cell death | ↑NF-κB | [129] |
| Micellar resveratrol + quercetin + ADR | A2780ADR xenograft model | Reduced tumor growth | Chemosensitization | [130] |
| Micellar resveratrol + quercetin + ADR; micellar resveratrol + curcumin + ADR | ES2-Luc xenograft model | Reduced tumor volume | Chemosensitization | [130] |
↓: downregulated; ↑: upregulated; VEGF, vascular endothelial growth factor; NF-κB, nuclear transcription factor-kappa B; I3C, indole-3 carbinol; Rb, retinoblastoma protein; SVV, survivin; TGF-β, transforming growth factor-beta; ADR, adriamycin; ES2-Luc, human ovarian clear cell carcinoma cells (ES2) transfected with luciferase; A2780ADR, ADR-resistant human ovarian epithelial cancer cells.