Table 4.
Bioactive compounds from deep-sea Porifera.
| Marine Organism | Compound | Activity/Experimental Model | Depth/Site | Concentration | Ref. |
|---|---|---|---|---|---|
| Petrosia sp. | (−)-Duryne and (−)-Durynes B–F | Cytotoxic against HeLa cells | 415 m Japan |
IC50 from 0.08 to 0.5 μM | [73] |
| Xestospongia sp. | Alisiaquinones A–C | Antimalarial against Plasmodium falciparum |
250/400 m Australia |
Submicromolar | [74] |
| Leiodermatium sp. | Leiodermatolide | Antimitotic | 401 m USA |
IC50 < 10 nM | [75] |
| Latrunculia sp. | Discorhabdin A and Dihydrodiscorhabdin C | Anti-HCV | 230 m Alaska |
EC90 < 10 μM | [76] |
Abbreviations: IC50 for the concentration (μg/mL) inducing 50% loss of cell viability; EC90 for the 90% effective concentration in the HCV replicon assay; less than 10 μM is considered active. HCV for hepatitis C virus. HeLa cervical cancer cell lines.