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. 2021 Oct 28;9(11):1556. doi: 10.3390/biomedicines9111556

Table 5.

Bioactive compounds from deep-sea mesopelagic organisms.

Marine Organism Activity/Experimental Model Depth/Site Concentrations Ref.
Myctophum punctatum Antiproliferative activity against A549 and MCF7 200–1000 m
Straits of Messina
(central Mediterranean Sea)		 IC50 = 13.77–23.26 and 25.34–29.62 μg/mL, respectively [77]
Antibacterial activity against MRSA IC50 = 40 and 320 μg/mL
Meganyctiphanes norvegica Antiproliferative activity against HepG2 200–1000 m
Straits of Messina
(central Mediterranean Sea)		 IC50 = 3.81 and 7.51 μg/mL [77]
Antibacterial activity against MRSA IC50 = 80–320 μg/mL

Abbreviations: IC50 for the concentration (μg/mL) inducing 50% loss of cell viability; MCF7 for breast cancer cell line; A549 for lung cancer cells; MRSA for methicillin resistant Staphylococcus aureus; MSSA for methicillin sensitive Staphylococcus aureus.