Table 6.
Synopsis of new natural products isolated from deep-sea organisms.
| Phylum | Marine Organism | Compound | Activity/Experimental Model | Depth/Site | Concentration | Ref. |
|---|---|---|---|---|---|---|
| Chordata | Aplidium sp. | Rossinones A and B | Antileukemic, anti-inflammatory and antiviral against HSV-1 |
200 m Antarctica |
IC50 = 1.9 and 2.5 μM 2 μg/disk |
[78] |
| Echinodermata | Holopus rangii | Gymnochromes E and F | Antiproliferative against NCI/ADRRes | 358 m Caribbean |
IC50 = 3.5 μM | [79] |
| Mollusca | Bathymodiolus thermophilus | Bathymodiolamides A and B | Anticancer against HeLa and MCF-7 cell lines | 1733 m Mid-Atlantic ridge |
IC50 = 0.4 μM and 0.5 μM; IC50 = 0.1 μM and 0.2 μM |
[80] |
Abbreviations: IC50 for the concentration (μg/mL) inducing 50% loss of cell viability. NCI/ADRRes multidrug-resistant ovarian cancer cell line; HSV-1 for herpes simplex-1. HeLa for cervical cancer cells, MCF7 for breast cancer cell.