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. 2021 Nov 11;10(11):1384. doi: 10.3390/antibiotics10111384

Figure 2.

Figure 2

Sites of mutations in 23S rRNA (A) Secondary structure of Rhodothermus marinus 23S rRNA in the vicinity of the thiostrepton binding site, indicating in blue the sites of single base substitution (A1067C), single base deletion (ΔA1069) and single nucleotide insertions (A1069AA and G1071GG), each conferring thiostrepton-resistance (ThiR). (B) Three-dimensional structure of the thiostrepton binding site in the crystal structure of the Deinococcus radiodurans 70S ribosome-thiostrepton complex (pdb entry 3cf5) [29]. Thiostrepton (green sticks); ribosomal protein uL11 (palecyan); 23S rRNA, white cartoon backbone with skyblue residues mutated to confer resistance in R. marinus. A1095 is colored pink. The 2′OH of A1067, site of methylation by resistance methyltransferases, is shown as a pink sphere.