Skip to main content
. 2021 Oct 26;10(11):1685. doi: 10.3390/antiox10111685

Figure 7.

Figure 7

Role of System Xc− and NMDA receptor activation on the viability of Aβ-treated SH-SY5Y differentiated cells. (A) SH-SY5Y cells were grown in mono-cultures and treated for 24 h with Aβ25-35 (50 μM). (B) SH-SY5Y cells were co-cultured with U373 cells and treated for 24 h with Aβ25-35 (50 μM) alone or in the presence of either SSZ (300 μM) or MK801 (10 μM). MTT cell viability assay was carried out as specified in Materials and Methods. The histograms show the percentage of living cells, and the rate of reduction was calculated by setting the control (CTRL) equal to 100%. Values are the means ± SEM from three separate experiments, each performed in duplicate. One-way ANOVA, followed by Bonferroni’s test, was used to determine significant differences. NS not significant; ** p ≤ 0.01 between CTRL and Aβ25-35; ** p ≤ 0.01 between Aβ25-35 and Aβ25-35 + SSZ; * p ≤ 0.05 between Aβ25-35 and Aβ25-35 + MK801.