Table 4.
The gene identification for a protein, protein name, log2 fold change, and p value adjusted for multiple test corrections in five geldings supplemented with NACQ compared to placebo.
| Gene ID | Protein Name | Adjusted p Value | Log2 Fold Change |
|---|---|---|---|
| Increased expression | |||
| MB | Myoglobin | 1.90 × 10−3 | 0.22 |
| Mitochondria | |||
| TCA cycle | |||
| IDH2 | Isocitrate Dehydrogenase [NADP] Mitochondrial | 2.10 × 10−4 | 0.12 |
| ACO2 | Aconitate Hydratase Mitochondrial | 5.00 × 10−4 | 0.11 |
| MDH2 | Malate Dehydrogenase Mitochondrial | 4.00 × 10−3 | 0.11 |
| FH | Fumarate Hydratase Mitochondrial | 2.00 × 10−3 | 0.11 |
| OGDH | 2-Oxogluterate Dehydrogenase Mitochondrial Isoform X3 | 8.70 × 10−4 | 0.09 |
| Electron Transfer System | |||
| COX5A | Cytochrome C Oxidase Subunit 5A Mitochondrial | 8.90 × 10−4 | 0.18 |
| COX4I1 | Cytochrome C Oxidase Subunit 4 Isoform 1 Mitochondrial | 5.00 × 10−4 | 0.13 |
| ATP5F1B | ATP Synthase Subunit beta Mitochondrial | 1.00 × 10−4 | 0.10 |
| Fat metabolism | |||
| ACADVL | Very Long-Chain Specific Acyl-CoA Dehydrogenase Mitochondrial | 1.00 × 10−3 | 0.11 |
| ASCL1 | Long-Chain-Fatty-Acid–CoA Ligase 1 Isoform X2 | 2.70 × 10−3 | 0.10 |
| FABP3 | Fatty Acid-Binding protein Heart | 1.00 × 10−3 | 0.27 |
| Other | |||
| NNT | NAD(P) Transhydrogenase Mitochondrial Isoform X1 | 3.00 × 10−3 | 0.07 |
| VDAC2 | Voltage-Dependent Anion-Selective Channel Protein 2 | 2.00 × 10−3 | 0.14 |
| Sarcomere Proteins | |||
| Z disc | |||
| CRYAB | Alpha-Crystallin B Chain | 1.00 × 10−4 | 0.28 |
| ACTN2 | Alpha-Actinin-2 Isoform X1 | 1.00 × 10−4 | 0.16 |
| FLNC | Filamin-C Isoform X1 | 1.30 × 10−4 | 0.12 |
| PDLIM5 | PDZ and LIM Domain Protein 5 Isoform X9 | 7.20 × 10−4 | 0.12 |
| Myosin | |||
| MYBPC1 | Myosin-Binding Protein C Slow-Type Isoform X2 | 1.00 × 10−4 | 0.11 |
| Blood Proteins | |||
| ALB | Serum Albumin Precursor | 1.00 × 10−4 | 0.38 |
| APOA1 | Apolipoprotein A-I | 1.00 × 10−3 | 0.34 |
| LOC100061692 | Alpha-2 Macroglobulin | 3.50 × 10−3 | 0.22 |
| Decreased expression | |||
| Cysteine Synthesis | |||
| ARMT1 | Protein-Glutamate O-Methyltransferase | 7.30 × 10−4 | −0.40 |
| Glycolysis/Gluconeogenesis | |||
| PFKM | ATP-Dependent 6-Phosphofructokinase Muscle Type Isoform X3 | 2.00 × 10−3 | −0.07 |
| PKM | Pyruvate Kinase PKM Isoform M1 | 1.00 × 10−4 | −0.10 |
| LDHA | L-lactate Dehydrogenase A Chain | 1.80 × 10−4 | −0.10 |
| FBP2 | Fructose -1,6-bisphosphatase isozyme 2 | 4.00 × 10−3 | −0.11 |
| GPI | Glucose-6-Phosphate Isomerase | 1.00 × 10−4 | −0.14 |
| PHKA1 | Phosphorylase B Kinase Regulatory Subunit alpha Skeletal Muscle Isoform X1 | 1.00 × 10−3 | −0.14 |
| PHKB | Phosphorylase B Kinase Regulatory Subunit beta | 2.00 × 10−3 | −0.14 |
| ENO3 | Beta-Enolase | 1.00 × 10−4 | −0.15 |
| PGM1 | Phosphoglucomutase-1 Isoform X2 | 1.00 × 10−4 | −0.15 |
| Sarcomere | |||
| MYOM1 | Myomesin-1 Isoform X4 | 1.00 × 10−3 | −0.08 |
| MYOM2 | Myomesin-2 Isoform X3 | 1.00 × 10−4 | −0.12 |
| MYH1 | Myosin-1 Isoform X1 | 2.70 × 10−4 | −0.11 |
| MYBPC2 | Myosin-Binding Protein C Fast-Type | 1.00 × 10−4 | −0.17 |
| MYLK2 | Myosin Light Chain Kinase 2 Skeletal/Cardiac Muscle | 2.50 × 10−3 | −0.20 |
| Calcium Regulation | |||
| SRL | Sarcalumenin Isoform X1 | 1.00 × 10−3 | −0.09 |
| ATP2A1 | Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 1 Isoform X1 | 1.00 × 10−4 | −0.17 |
| ANXA6 | Annexin A6 Isoform X1 | 1.00 × 10−4 | −0.13 |