Table 2.
The effect of the isolated compounds on fasting blood glucose, insulin, and insulin resistance indices in the experimental rats.
| Groups | FBG (mg/dL) | Insulin (μIU/mL) | HOMA-IR | QUICKI |
|---|---|---|---|---|
| Normal | 93.2 ± 9.26 | 10.89 ± 2.85 | 2.53 ± 0.79 | 0.33 + 0.03 |
| Control (HFD + STZ) | 277.28 ± 28.17 * | 44.17 ± 4.71 * | 30.09 ± 4.30 * | 0.24 ± 0.03 * |
| C1 (Rutin) | 218.07 ± 23.37 *# | 34.64 ± 4.83 *# | 18.84 ± 3.00 *# | 0.26 ± 0.02 * |
| C2 (Quercetin 3-O-neohesperdoside) | 251.34 ± 25.48 * | 39.92 ± 4.92 * | 24.79 ± 3.87 * | 0.25 ± 0.02 * |
| C3 (Quercetin-3-O-β-galactoside) | 120.93 ± 12.83 *# | 19.21 ± 3.09 *# | 5.68 ± 1.03 *# | 0.30 ± 0.02 *# |
| C4 (Isoquercetrin) | 262.25 ± 27.30 * | 41.66 ± 4.48 * | 27.17 ± 3.01 * | 0.25 ± 0.02 * |
| C5 (Quercetin) | 198.39 ± 20.37 *# | 31.51 ± 3.98 *# | 15.16 ± 2.04 *# | 0.26 ± 0.03 * |
Data are expressed as mean ± SD and analyzed using one-way ANOVA followed by Bonferroni’s post hoe test (n = 6-8). FBG = fasting blood glucose; HOMA-IR = homeostasis model assessment-insulin resistance; QUICKI = quantitative insulin sensitivity check index; * significantly different compared to the normal group at p < 0.05; at p < 0.001; # significantly different compared to the T2DM control group (high fat diet + Streptozotocin) at p < 0.05.