Table 4.
The effect of the isolated compounds on the liver index, liver enzymes, and liver content of lipids in the experimental rats.
| Groups | Liver Index % | ALT (IU/L) | AST (IU/L) | Liver TG (mg/g) | Liver TC (mg/g) |
|---|---|---|---|---|---|
| Normal | 2.55 ± 0.25 | 49.27 ± 5.70 | 68.83 ± 7.45 | 5.90 ± 0.88 | 3.20 ± 0.52 |
| Control (HFD + STZ) | 3.51 ± 0.28 * | 77.12 ± 8.13 * | 91.73 ± 9.32 * | 14.33 ± 2.90 * | 7.80 ± 1.00 * |
| C1 (Rutin) | 2.98 ± 0.15 *# | 63.43 ± 6.80 *# | 78.86 ± 8.47 | 8.50 ± 1.59 *# | 5.32 ± 0.71 *# |
| C2 (Quercetin 3-O-neohesperdoside) | 3.14 ± 0.16 * | 67.85 ± 7.47 *# | 82.48 ± 8.25 * | 10.48 ± 1.99 *# | 5.55 ± 0.82 *# |
| C3 (Quercetin-3-O-β-galactoside) | 2.66 ± 0.14# | 54.68 ± 6.30# | 71.62 ± 7.33 # | 7.60 ± 1.01 # | 4.44 ± 0.62 # |
| C4 (Isoquercetrin) | 3.30 ± 0.17 * | 72.21 ± 7.49 * | 86.10± 9.08 * | 11.35 ± 2.20 *# | 5.81 ± 0.81 *# |
| C5 (Quercetin) | 2.82 ± 0.14 *# | 59.00 ± 6.50 # | 75.24 ± 8.09 # | 8.10 ± 1.57 *# | 4.92 ± 0.67 *# |
Data are expressed as mean ± SD and analyzed using one-way ANOVA followed by Bonferroni’s post hoe test (n = 6–8). ALT = alanine aminotransferase; AST = aspartate aminotransferase; TG = triglycerides; TC = total cholesterol; * significantly different compared to the normal group at p < 0.05; # significantly different compared to the T2DM control group (high fat diet + Streptozotocin) at p < 0.05.