Table 2.
Notable anticancer agents targeting mitochondrial metabolism.
| Anticancer Agents | Target Site | Effect on Mitochondrial Metabolism |
|---|---|---|
| Metformin/Phenformin | Complex I | Decrease ATP production [225] |
| VLX600 | ETC | Decrease ATP production [226] |
| C-968 | Glutaminase | Suppress contribution of glutamine to the TCA cycle [227] |
| Chloroquine | Autophagy | Suppress contribution of autophagy to the TCA cycle [228] |
| ATN-224 | SOD1 | Increase accumulation of ROS causing cell death [224] |
| CPI-613 | TCA cycle | Induce mitochondrial ROS production causing cell death [229] |
| Leflunomide | DHODH | Inhibit ETC-dependent pyrimidine biosynthesis [230] |