Table 4.
Summary of normalized oxidative stress and inflammatory systemic circulatory markers.
| Variable | (19–30) Year |
(31–50) Year |
(51–70) Year |
p-Value Anova/Ancova |
Post-Hoc |
|---|---|---|---|---|---|
| 7-KC (nmol/mmol) |
10.49 (1.71) | 13.28 (1.17) | 17.26 (1.17) | 0.0051 * | 1 < 2 < 3 |
| 25-OHC (nmol/mmol) | 16.42 (3.86) | 20.86 (2.65) | 30.56 (2.65) | 0.0067 * | 1 < 2 < 3 |
| 27-OHC (nmol/mmol) | 16.61 (3.05) | 20.55 (2.09) | 26.79 (2.09) | 0.0192 * | 1 < 2 < 3 |
| 4β-OHC (nmol/mmol) | 1.02 (0.35) | 0.81 (0.24) | 1.14 (0.24) | 0.6054 | - |
| 7β-OHC (nmol/mmol) | 6.65 (1.70) | 9.86 (1.17) | 12.74 (1.17) | 0.0168 * | 1 < 2 < 3 |
| 7,27-OHC (nmol/mmol) | 8.45 (2.30) | 8.64 (1.57) | 10.65 (1.57) | 0.5986 | - |
| 7,25-OHC (nmol/mmol) | 5.60 (2.60) | 8.89 (1.78) | 11.41 (1.80) | 0.0113 * | 1 < 2 < 3 |
| NO (uM) | 46.45 (4.37) | 43.02 (3.39) | 39.73 (3.10) | 0.4495 | |
| IL-6 (pg/mL) | 3.23 (0.45) | 3.24 (0.31) | 3.09 (0.31) | 0.9424 | - |
| GSH/GSSG | 27.25(7.95) | 20.84 (7.95) | 17.05 (8.60) | 0.0279 * | 1 > 2 > 3 |
Abbreviations: ANOVA, analysis of variance; ANCOVA, analysis of covariance; 7-KC, 7-Ketocholesterol; 25-OHC, 25-Hydroxycholesterol; 27-OHC, 27-Hydroxycholesterol; 4β-OHC, 4β-Hydroxycholesterol; 7β-OHC, 7β-Hydroxycholesterol; 7,27-OHC, 7,27-Hydroxycholesterol; 7,25-OHC, 7,25-Hydroxycholesterol; NO, nitric oxide; IL-6, interleukine-6; GSH, glutathione; GSSG, Glutathione disuphide; GSH/GSSG, redox ratio. * Significant p-values are indicated where p < 0.05 was considered significant.