Table 3.
Adapted pharmacokinetic parameters used in Monte Carlo simulations [5].
| Drug [Ref] |
Cefepime [18,19,20,21,22,23] |
Ceftazidime [24,25,26,27,28,29] |
Ertapenem [5,30] |
Imipenem [5,30] |
Meropenem [5,30] |
Piperacillin [23,31,32,33,34] |
Tazobactam [23,33] |
|---|---|---|---|---|---|---|---|
| Vd (L/kg) | 0.48 ± 0.24 (0.16–1.11) |
0.34 ± 0.20 (0.13–1.1) |
0.19 ± 0.07 (0.13–0.34) |
0.34 ± 0.1 (0.21−0.63) |
0.41 ± 0.18 (0.08−1.07) |
0.40 ± 0.21 (0–1.11) |
0.50 ± 0.37 (0–2.13) |
| Free Fraction |
0.79 ± 0.09 (0.72–0.85) |
0.86 ± 0.05 (0.75–0.94) |
0.25 ± 0.45 (0−1) |
0.8 ± 0.16 (0−1) |
0.79 ± 0.09 (0−1) |
0.76 ± 0.2 (0–1) |
0.74 ± 0.27 (0–1) |
| NR CL (mL/min) | 24.33 ± 11.25 (13–44) |
15.9 ± 9.9 (8–37.7) |
11 ± 3 (10−19) |
100.5 ± 28 (53−160) |
54.9 ± 49 (0−251) |
48.5 ± 37 (0–187) |
40.4 ± 70 (0–381) |
| Sieving coefficient |
0.67 ± 0.13 (0–1) |
0.85 ± 0.05 (0–1) |
0.2 ± 0.06 (0−1) |
0.57 ± 0.1 (0−1) |
0.63 ± 0.13 (0−1) |
0.6 ± 0.28 (0–1) |
0.8 ± 0.36 (0–1) |
| r2 weight and Vd | 0.4197 | 0.0237 | 0.3318 | 0.17 | 0.1435 | 0.0567 | 0.0049 |
| r2 weight and NR CL |
0.038 | 0.1254 | 0.1156 | 0.013 | 0.0072 | 0.036 | 0.0098 |
| Weight ± SD (kg) | Less intensive: 84.1 ± 18.9; Intensive: 84.1 ± 19.6 | ||||||
| CRRT % delivered |
Less intensive: 0.95 ± 0.35 (0–1); Intensive: 0.89 ± 0.39 (0–1) | ||||||
| Qeff (mL/kg/h) | Less intensive: 22 ± 6.1 (0–47.5) vs. Intensive: 35.8 ± 6.4 (0–47.5) | ||||||
| Qrep (L/h) | Less intensive: 0.83 ± 0.25 (0.33–1.33); Intensive: 0.89 ± 0.39 (0–1) | ||||||
All values are mean ± standard deviation (minimum–maximum limits). Abbreviations: CL = clearance; NR = nonrenal; r2 = correlation; Vd = volume of distribution; Qeff = effluent flow rate; Qrep = replacement fluid rate.