Figure 4.

Overall structure of DrTrx2. (A) Cartoon representation of the full-length structure of DrTrx2. The molecule is colored progressively, from blue at the N-terminus to red at the C-terminus. The four α-helices (α1-α4) and seven β-sheets (β1–β7) are labelled. One zinc ion bound to the N-terminal zinc-finger domain is shown as a gray sphere. (B) Surface conservation of the DrTrx2. The sequence conservation pattern of DrTrx2 was obtained using the Consurf server. Cartoon representation of DrTrx2 shown at the same orientation as (A) with a transparent surface. Residues are colored from magenta to cyan with a descending order of conservation, as shown in the color-coding bar below. The active site WCGPC motif, the zinc binding cysteines, and a zinc ion are labelled.