Table 1.

Interventions that modulate SIRT3 signaling in hypertension.

Experimental Model	Intervention	The Effect of Intervention	Reference
Wild type mice	Angiotensin II induced hypertensive renal nephropathy	Decreased kidney SIRT3 expression; HT; Decreased renal function;	[120]
SIRT3 KO mice	Angiotensin II induced hypertensive renal nephropathy	Hypertensive nephropathy, renal fibrosis;
Wild type mice	Angiotensin II induced hypertensive renal nephropathy + Honokiol (bioactive compound from Magnolia officinalis)	↑ Renal function; ↑ SIRT3 expression; ↓ Kidney fibrosis; Activates SIRT3-KLF15 signaling pathway.
Male newborn rats	Short-term sucrose ingestion in the early post-natal period	↑ Blood pressure; ↓ Aortic SIRT3, SOD2 and endothelial NO synthase expression; ↑ Energy supply, ↓NADH to NAD+ oxidation; ↓SIRT3 activity.	[121]
Spontaneously hypertensive rats	α-Linolenic acid	↓ HT; ↑ Endothelial function; Prevents HT-induced SIRT3 reduction and SOD2 hyperacetylation; ↓ Endothelial mtROS; Improvements were SIRT3-dependent.	[122]
Human umbilical vein endothelial cells	Resveratrol	↓ Oxidative damage, mtROS, apoptosis; ↑ Cell viability; Activates AMPK-PGC-1α signaling, ↑ SIRT3 transcription, ↑ deacetylation+activation of mtROS clearing enzymes, ↑ complex 1 activity and ATP synthesis.	[123]

Abbreviations: ↑ increases, ↓ decreases.