Table 2.

The treatment using ADSCs and the negative side effect in In-vitro and In vivo.

Source	Treatment	Type of Study	Method	Results	Ref(s)
ADSCs from mouse abdominal tissue	Colon and Breast Cancer	In-vitro and in-vivo	Co-culture (in vitro) Inoculated 4T1 or CT26 cells with or without ADSCs into BALB/c mice (In vivo)	Both in-vitro and in-vivo studies showed ADSCs accelerate cancer growth. ADSC interaction with cancer cells could stimulate increased secretion of IL-6 mainly from ADSCs	[35]
ADSCs’ cell	Cervical cancer cell	In-vitro and in-vivo	Co-culture (In vitro) Injection on 6-week-old BALB/c nude mice. (In vivo)	ADSCs promoted cervical cancer growth and invasion through paracrine secretion of HGF and involvement of the HGF/c-MET signaling pathway. ADSCs secreted a high level of HGF into the supernatant	[36]
ADSC from omentum tissue	Epithelial Ovarian Cancer	In-vitro	Co-culture of cancel cells with ADSC	Both indirect and direct co-culture with ADSCs increased proliferation and migration ability in EOC cells to a similar extent, suggesting that the tumor-promoting effects of ADSCs are mainly mediated by the paracrine of ADSCs. MMPs released by ADSC contributed to the tumor-promoting effects of ADSCs In-vitro and In vivo.	[24]