Table 1.
The table shows the percentage of centronucleated fibers, quantified via qualitative analysis on H&E stained sections of diaphragm (DIA) and gastrocnemius (GC) muscles (10× magnification) from all mice cohorts. Values are expressed as mean ± SEM from the number of mice indicated in brackets. A statistically significant difference among groups was found by one-way ANOVA for both DIA (F = 7.5, p = 0.002) and GC (F = 64, p = 0.0001). Bonferroni post hoc test for individual differences between groups is as follows: * vs. WT (0.0001 < p < 0.002); N.S. vs. mdx + vehicle (p > 0.05).
Group | Centronucleated Fibers (%) | |
---|---|---|
DIA | GC | |
WT (n = 5) | 1.02 ± 0.32 | 1.95 ± 0.44 |
mdx + vehicle (n = 5) | 26.1 ± 2.7 * | 68.2 ± 3.4 * |
mdx + DAS/HP-β-CD10% 10 mg/kg (n = 7) | 23.6 ± 4.7 * | 76.1 ± 2.7 * |
mdx + DAS/HP-β-CD10% 20 mg/kg (n = 8) | 21.1 ± 2.9 * | 74.3 ± 3.7 * |