Table 2.
The table shows the mass of hind limb tibialis anterior (TA), extensor digitorum longus (EDL), quadriceps (QUAD), gastrocnemius (GC), and soleus (SOL) muscles, and the mass of vital organs (liver, heart, kidneys, spleen, and brain), normalized to mice body mass (BM), in mg/g, for all the experimental groups. Values are expressed as mean ± SEM from the number of mice indicated in brackets. A statistically significant difference among groups was found by one-way ANOVA for TA (F = 20.06, p < 0.0001), QUAD (F = 16.22, p < 0.0001), GC (F = 10.73, p < 0.0001), and SOL (F = 3.08, p = 0.05), and for vital organs, as well as for liver (F = 5.98, p = 0.003) and brain (F = 6.2, p = 0.003). Bonferroni post hoc test for individual differences between groups is as follows: * vs. WT (0.0001 < p < 0.05); N.S. vs. mdx + vehicle (p > 0.05).
Group | Mass of Hind Limb Muscles/BM (mg/g) | Mass of Vital Organs/BM (mg/g) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
TA | EDL | QUAD | GC | SOL | Liver | Heart | Kidneys | Spleen | Brain | |
WT (n = 6) | 1.57 ± 0.07 | 0.60 ± 0.22 | 6.72 ± 0.57 | 5.34 ± 0.15 | 0.27 ± 0.02 | 42.2 ± 1.5 |
4.78 ± 0.17 | 6.71 ± 0.15 | 2.81 ± 0.10 | 13.6 ± 0.23 |
mdx + vehicle (n = 7) | 2.30 ± 0.10 * | 0.44 ± 0.01 | 9.95 ± 0.37 * | 6.36 ± 0.11 * | 0.34 ± 0.03 | 49.8 ± 1.4 * |
4.79 ± 0.11 | 6.41 ± 0.08 | 3.03 ± 0.09 | 11.9 ± 0.67 |
mdx + DAS/HP-β-CD10% 10 mg/kg (n = 8) | 2.27 ± 0.06 * | 0.37 ± 0.02 | 9.86 ± 0.20 * | 6.14 ± 0.11 * | 0.37 ± 0.03 | 47.7 ± 1.0 * |
4.78 ± 0.12 | 6.89 ± 0.53 | 3.13 ± 0.08 | 12.1 ± 0.32 |
mdx + DAS/HP-β-CD10% 20 mg/kg (n = 8) | 2.23 ± 0.06 * | 0.37 ± 0.02 | 9.48 ± 0.32 * | 6.21 ± 0.16 * | 0.39 ± 0.03 | 47.8 ± 1.3 * |
5.01 ± 0.11 | 6.37 ± 0.11 | 2.97 ± 0.10 | 11.4 ± 0.39 |