Table 3.
Expression profile of the genes of the WNT pathway evaluated by nCounter Nanostring technology.
| Gene | Accession | Log2 Fold Change | p-Value | BH p-Value | Pathway Annotation |
|---|---|---|---|---|---|
| RUNX2 | NM_004348.3 | 4.25 | 0.00151 | 0.0887 | Development & Differentiation, Transcription Factors |
| CDKN2A | NM_000077.3 | 0.971 | 0.00187 | 0.0887 | Cell Cycle, Development & Differentiation, Transcription Factors |
| MAPK10 | NM_002753.2 | −4.76 | 0.002 | 0.0887 | KEGG WNT Annotation |
| EGFR | NM_201282.1 | −6.04 | 0.0028 | 0.0919 | Adhesion, Calcium Binding and Signaling, Cell Cycle, Development & Differentiation, Migration |
| SFRP1 | NM_003012.3 | 4.41 | 0.00411 | 0.0919 | Canonical Wnt Pathway, KEGG WNT Annotation, WNT Signaling Negative Regulation |
| TCF4 | NM_003199.1 | 0.661 | 0.00481 | 0.0919 | Transcription Factors |
| BMP4 | NM_001202.3 | 3.43 | 0.00524 | 0.0919 | Development & Differentiation |
| PLCB1 | NM_182734.1 | −3.82 | 0.00524 | 0.0919 | KEGG WNT Annotation |
| MMP7 | NM_002423.3 | −3.53 | 0.00556 | 0.0919 | Calcium Binding and Signaling, KEGG WNT Annotation, Proteolysis, WNT Signaling Target Genes |
| TGFB3 | NM_003239.2 | 0.978 | 0.00571 | 0.0919 | Development & Differentiation |
| PTGS2 | NM_000963.1 | −3.26 | 0.00834 | 0.123 | Calcium Binding and Signaling, Cell Cycle |
| TLE1 | NM_005077.3 | 1.8 | 0.0106 | 0.13 | WNT Signaling Negative Regulation |
| FZD5 | NM_003468.2 | −3.03 | 0.011 | 0.13 | Canonical Wnt Pathway, KEGG WNT Annotation |
| CXCL12 | NM_000609.5 | −3.11 | 0.0132 | 0.131 | EMTMetastasis |
| GDNF | NM_000514.2 | −2.85 | 0.0133 | 0.131 | Development & Differentiation, Migration |
| IRS1 | NM_005544.2 | 1.3 | 0.016 | 0.149 | Migration |
| FRAT1 | NM_005479.3 | 1.25 | 0.0185 | 0.164 | Canonical Wnt Pathway, KEGG WNT Annotation |
| FZD3 | NM_017412.2 | 0.699 | 0.0211 | 0.173 | Canonical Wnt Pathway, KEGG WNT Annotation |
| PPP3CC | NM_005605.4 | 0.552 | 0.0216 | 0.173 | KEGG WNT Annotation |
| SNAI2 | NM_003068.3 | −2.73 | 0.0249 | 0.191 | EMTMetastasis |
| KREMEN1 | NM_001039570.1 | −2.52 | 0.0268 | 0.191 | WNT Signaling Negative Regulation |
| FZD10 | NM_007197.2 | −2.43 | 0.027 | 0.191 | KEGG WNT Annotation |
| LEF1 | NM_016269.3 | 1.83 | 0.0334 | 0.22 | Canonical Wnt Pathway, KEGG WNT Annotation, Transcription Factors |
| NLK | NM_016231.2 | 0.519 | 0.0342 | 0.22 | KEGG WNT Annotation, WNT Signaling Negative Regulation |
| SOX2 | NM_003106.2 | −1.74 | 0.0348 | 0.22 | Cell Cycle, Development & Differentiation, Transcription Factors |
| PPP3CA | NM_000944.4 | 1.06 | 0.0401 | 0.237 | KEGG WNT Annotation |
| CXCR4 | NM_003467.2 | −1.63 | 0.0418 | 0.237 | EMTMetastasis |
| BIRC5 | NM_001168.2 | −0.491 | 0.0427 | 0.237 | Cell Cycle |
| WNT10B | NM_003394.2 | −1.26 | 0.0442 | 0.237 | KEGG WNT Annotation |
| SERPINE1 | NM_001165413.1 | −2.36 | 0.0442 | 0.237 | EMTMetastasis |
| TCF7L1 | NM_031283.1 | 0.931 | 0.0477 | 0.24 | Canonical Wnt Pathway, KEGG WNT Annotation, Transcription Factors |
| FZD8 | NM_031866.1 | −2.35 | 0.0479 | 0.24 | Canonical Wnt Pathway, KEGG WNT Annotation |
| SMAD2 | NM_005901.5 | 0.165 | 0.0488 | 0.24 | EMTMetastasis, KEGG WNT Annotation |