Figure 3.

Effect of MitoCINs, quinone-based mitochondria-targeted and non-targeted antioxidants on metabolic activity. Human Caucasian hepatocyte carcinoma (HepG2, (A,B)) and differentiated human neuroblastoma (SH-SY5Y, (C,D)) were treated with increasing concentrations of the different molecules for a period of 48 h and metabolic activity was evaluated using resazurin reduction assay. Data are the mean ± SE of four independent experiments and the results are expressed as a percentage of the control (control = 100%). Statistically significant differences between control (CTL) and treated groups were evaluated using a t-test. **** p < 0.0001, *** p < 0.001, ** p < 0.01 and * p < 0.05 compared to the respective control (CTL).