Figure 1.

Characterization of neuroblastoma cell lines. (A) XTT viability assay after 72 h incubation with 0.1–40 μM VIP116. IC₅₀ values are listed in Table 1. Pooled data from four independent experiments (mean ± SD). (B) Cellular specificity of ¹⁷⁷Lu-DOTATATE. Uptake of ¹⁷⁷Lu-DOTATATE without (black bars) or with (grey bars) blocking. Data from one representative experiment (mean ± SD, n = 4). n.s. = not significant, ** = p < 0.01, *** = p < 0.001 and **** = p < 0.0001. (C) Real-time uptake of ¹⁷⁷Lu-DOTATATE in IMR-32 cells in room temperature (grey) or at 37 °C (black) with 1:1 (red) or 1:2 (green) kinetic models. Data from one representative experiment.