Table 1.

p53 status, MYCN status and IC₅₀ values from XTT and spheroid monotherapy assays. IC₅₀ data is presented as mean value (95% CI). wt = wildtype, mut = mutated, n.e. = not established, del = deletion, amp = amplified, n.amp = not amplified, Sph = spheroid assay, Ref = additional references for p53 and MYCN status.

Cell Line	p53 Status	MYCN Status	XTT VIP116 (μM)	Sph. VIP116 (μM)	Sph. 177Lu-DOT (kBq/well)	Ref.
IMR-32	wt	amp	13.2 (11.1–15.4)	15.3 (12.7–18.1)	0.12 (0.10–0.14)	[35,47,48]
NB1	wt	amp	2.9 (2.3–3.7)	0.9 (0.8–1.0)	1.1 (0.8–1.5)	[39]
NB2	wt	amp	2.8 (2.6–3.0)	1.4 (1.2–1.6)	0.88 (0.67–1.21)	[38]
N2a	mut 1	amp	238.2 (60.5–105) 3	n.e.	n.e.	[49]
SKNAS	del 2	n.amp	40.8 (27.8–45.4) 3	n.e.	n.e.	[35,50,51]

¹ Missense mutation in the DNA-binding domain of exon 5. Only exon 2 and 4–11 were sequenced. ² No visible PCR product of exon 10 and 11, supported by additional references. ³ A total of 50% inhibition was not reached at the maximum concentration.