Table 1.

Genes involved in cholesterol and lipid metabolism in HUVEC that are differentially regulated by CD63⁺ vs. MHC-I⁺ EVs and miRNAs known to regulate these genes that differ in CD63⁺ and MHC-I⁺ EVs released by WT Jurkat T cells.

Gene	Function 1	CD63+ EV vs. UT (Fold)	p Value	MHC-I+ EV vs. UT (Fold)	p Value	miRNAs Differing in CD63+ vs. MHC-I+ EVs 2
LDLR	cholesterol uptake	2.0	2.8 × 10−6	1.93	5.2 × 10−6	miR-140, miR-185, miR-130b
SREBF2	cholesterol biosynthesis	1.5	0.00032		NS	miR-185
INSIG1	cholesterol biosynthesis	2.81	2.6 × 10−5	1.97	0.00124	miR-130b
HMGCR	cholesterol biosynthesis	2.1	0.032		NS
HMGCS1	cholesterol biosynthesis	2.99	0.0052		NS	miR-223
ACAT2	lipid/cholesterol metabolism	2.3	0.014		NS

¹ Data for target genes of the listed miRNAs are from [19]. NS, not significant. ² Differential export of the miRNAs in CD63⁺ and MHC-I⁺ EVs released by WT Jurkat T cells is from [13].