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. 2021 Nov 2;11(11):436. doi: 10.3390/bios11110436

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) Schematic diagram of the catalyzed mechanism of IR1048-MZ for hypoxia-activated NIR-II/PA tumor imaging. HOMO and LUMO energy levels of IR1048-MZ and IR1048-MZH were obtained by theoretical calculation. (b) Fluorescence spectra of IR1048-MZ with and without the addition of NTR. (c) NIR-II fluorescence spectra of IR1048-MZ (5 μg/mL) in response to various concentrations of NTR. (d) Time-dependent NIR-II fluorescence imaging of tumor-bearing mice after injection of IR1048-MZ (40 μg/mL, 200 μL). Reproduced with permission [126]. Copyright 2018, Creative Commons.