FDA |
Food and Drug Administration, |
MDSCs |
myeloid-derived suppressor cells, |
JAK1 |
Janus kinase 1, |
JAK2 |
Janus kinase 2, |
B2M |
beta-2-microglobulin, |
MHC-I |
major histocompatibility complex class 1, |
STAT1 |
signal transducer and activator of transcription 1, |
IFNGR1 |
interferon gamma receptor 1, |
PTPN2 |
protein tyrosine phosphatase non-receptor type 2, |
APLNR |
apelin receptor, |
PBRM1 |
polybromo 1, |
ARID2 |
AT-rich interaction domain 2, |
BRD7 |
bromodomain containing 7, |
USP22 |
ubiquitin-specific peptidase 22, |
PTEN |
phosphatase and tensin homolog, |
CDKN2A |
cyclin-dependent kinase inhibitor 2A, |
SK1 |
sphingosine kinase-1, |
HLA-I |
human leukocyte antigen class I, |
APM |
antigen-processing machinery, |
NGFR |
nerve growth factor receptor, |
FMT |
fecal microbiome transplantation, |
TMB |
tumor mutation burden, |
ADAR1 |
adenosine deaminase acting on RNA 1, |
ICAM1 |
intercellular adhesion molecule 1, |
AUC |
area under curve, |
CAFs |
cancer-associated fibroblasts, |
BLIMP-1 |
B lymphocyte-induced maturation protein-1, |
TIM3 |
T cell immunoglobulin domain and mucin domain 3, |
BTLA |
B and T lymphocyte associated, |
TAMs |
tumor-associated macrophages, |
irAEs |
immune-related adverse events, |
DCs |
dendritic cells, |
STAT5 |
signal transducer and activator of transcription 5, |
SHIP1 |
Src homology-2 domain-containing inositol 5-phosphatase 1, |
SOCS1 |
suppressor of cytokine signaling 1, |
BACH1 |
BTB domain and CNC homolog 1, |
CEBPB |
CCAAT enhancer binding protein beta, |
IL7R |
interleukin 7 receptor, |
NF-κB |
nuclear factor kappa B, |
AP-1 |
activator protein 1, |
PTPRC |
protein tyrosine phosphatase receptor type C, |
BCL6 |
B-cell lymphoma-6 protein, |
IL13Rα1 |
interleukin 13 receptor alpha1, |
AKT1 |
AKT serine/threonine kinase 1, |
IRAK1 |
interleukin 1 receptor-associated kinase 1, |
TRAF6 |
TNF receptor-associated factor 6, |
STAT6 |
signal transducer and activator of transcription 6, |
IRF4 |
interferon regulatory factor 4, |
PPAR-γ |
peroxisome proliferator activated receptor gamma, |
KLF13 |
Kruppel-like factor 13, |
LIPA |
lysosomal acid lipase A, |
EVs |
extracellular vesicles, |
SMAD7 |
SMAD family member 7, |
IGF2R |
insulin-like growth factor 2 receptor, |
VEGFA |
vascular endothelial growth factor A, |
FGF2 |
fibroblast growth factor 2, |
NLK |
Nemo-like kinase, |
ULBP2 |
UL16 binding protein 2, |
TAP1 |
antigen processing 1, |
HLA-A |
major histocompatibility complex class I, A, |
BMDCs |
bone marrow-derived dendritic cells, |
cDC1s |
conventional DC1s, |
CXCL |
C-X-C motif ligand, |
MMPs |
matrix metalloproteinases, |
JNK |
c-Jun N-terminal kinase, |
MITF |
microphthalmia-associated transcription factor, |
TYR |
tyrosinase, |
MLANA |
Melan-A/Mart-1, |
CTL |
cytolytic T lymphocytes, |
TRAF6 |
TNFR-associated factor 6, |
IRAK1/2 |
Il-1R-associated kinase 1/2. |