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. 2021 Nov 11;11(11):1487. doi: 10.3390/brainsci11111487

Figure 3.

Figure 3

Dihexa ameliorated neuronal loss in the brains of APP/PS1 mice. (A) Nissl staining results of the effects of Dihexa on the neuronal cells in the cerebral cortex. Neurons with dark violet nucleus and intact morphology were identified as Nissl-positive neurons. Scale bar = 100μm. (B) Quantification analysis of Nissl-positive neuron percentage in cerebral cortex. (C) Expression of synaptophysin in mouse brains. (D) Densitometric analysis of synaptophysin protein expression. All data were analyzed by one-way ANOVA followed by Tukey’s post hoc test. Columns represent mean ± SD (n = 6 per group). * p < 0.05 vs. age-matched vehicle-treated WT control mice. # p < 0.05 vs. vehicle-treated APP/PS1 mice.