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Dihexa attenuated neuroinflammation and inhibited glial activation in the brains of APP/PS1 mice. (A–C) The levels of IL-1β, TNF-α, and IL-10 in the brain were investigated by ELISA. All data were analyzed by one-way ANOVA followed by Tukey’s post hoc test. (D–F). The expression of GFAP and Iba-1 and densitometric analysis of the two proteins. Columns represent mean ± SD (n = 6 per group). * p < 0.05 vs. vehicle-treated WT control mice. # p < 0.05 vs. vehicle-treated APP/PS1 mice.
