Table 1.

Mechanisms that generate alternative 3′UTR isoforms and their impact on miRNA binding. Shown are the transcript affected, the mechanism of 3′UTR shortening, the miRNA binding sites lost in the isoform affected, the cells/disease in which the 3′UTR were detected and the reference of the work. See text for more details.

mRNA	Alternative 3′UTR	miRNAs	Cells/Disease	Reference
Igf1	APA	LF:miR-29,miR-365	Osteoblastic differentiation	[103]
CCND1	APA	LF:over80miRNAs	Mantle cell lymphoma	[104]
Ki-67	APA	LF:miR-133-3p,miR-140-3p	Breast cancer	[105]
FNDC3B	APA	LF:23miRNAs	Nasopharyngeal carcinoma	[106]
Tau	APA	LF:miR-34a	Neuroblastoma cell lines	[107]
PolH	APA	LF:miR-619	Lung or bladder cancer	[108]
ABCB1	APA	LF:miR-508-5p,miR-145	Leukemia cells	[109]
ABCC2	APA	LF:miR-379	Hepatoma cell line	[110]
COX-2	APA	n.s.	Colon tumors	[111]
Hsp70.3	APA	LF:miR-378	Cardiac ischemic	[112]
AAMDC	APA	LF:miR-2428/664a	Adipogenesis	[113]
Many	APA *	n.s	Mammalian brain	[114]
CYP20A1_Alu-LT	Exonized Alus	Over 140 miRNAs	Primary neurons	[115]
NR2C1,GTSE1,FHL2,RAD1,FKBP9,CAD, SMA4	Exonized Alus	miR-15a-3p	HeLa cells	[116]
ADD1andUBE2I	Exonized Alus	miR-302d-3p	HeLa cells	[116]
387genes	Retained intron	n.s.	n.s.	[117]
CerS1	Retained intron	miRNA-574-5p	HNSCC	[118]
BCL11A	Alternative splicing	ExtraLF:miR-486-3p	Erythroid cells	[119]
BCL2	Alternative splicing	LF:miR-204	HCT116 human colon cancercells	[120]
ADAM12	Alternative splicing	LF:miR-29andmiR-200	Breast cáncer cells	[121]
SEMA6Ba	Alternative splicing	miR-218,miR-19 **	MCF-7cell line	[122]
CD34	Alternative splicing	LF:miR-193-5p,miR-125,miR-129-5p,miR-351-5p	Atherosclerosis	[123]

APA: alternative polyadenylation; HNSCC: head/neck squamous carcinoma; LF: long form; n.s.: non-stated; * Very distal polyadenylation sites used, likely encoded by downstream lincRNAs; ** internal sites lost by alternative splicing.