Table 2.
Cox multivariable regression nested models on each fibrosis-4 (FIB-4) score risk category (low-, intermediate-, and high-risk).
| FIB-4 Score | APRI Score | ||||
|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | ||
| Model 1 | Model 1 | ||||
| Intermediate FIB-4 score | 1.51 | 1.04 to 2.21 | Liver Fibrosis | 2.31 | 1.71 to 3.13 |
| High FIB-4 score | 3.01 | 2.24 to 4.06 | Probable Cirrhosis | 3.60 | 1.99 to 6.49 |
| Model 2 | Model 2 | ||||
| Intermediate FIB-4 score | 1.16 | 0.76 to 1.69 | Liver Fibrosis | 1.70 | 1.25 to 2.32 |
| High FIB-4 score | 1.76 | 1.28 to 2.41 | Probable Cirrhosis | 2.09 | 1.14 to 3.80 |
| Model 3 | Model 3 | ||||
| Intermediate FIB-4 score | 1.12 | 0.77 to 1.64 | Liver Fibrosis | 1.69 | 1.24 to 2.30 |
| High FIB-4 score | 1.80 | 1.31 to 2.47 | Probable Cirrhosis | 2.18 | 1.19 to 3.98 |
HR: hazard ratio; CI: confidence interval. Legend: FIB-4 score cutoffs: Low: <2.00; Intermediate: 2.00< x <2.67; High: >2.67. APRI, AST-to-Platelet Ratio Index: fibrosis-free (APRI < 0.50), liver fibrosis (APRI < 1.50), and probable cirrhosis (APRI ≥ 1.50). Model 1: Unadjusted. Model 2: Adjusted for age and sex. Model 3: Adjusted for age, sex, smoking habits, alcohol consumption, education, and multimorbidity.