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. 2021 Nov 17;11(11):1711. doi: 10.3390/biom11111711

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Optical density of ovarian cancer cells following a second round of classic chemotherapy. Spheroids were pretreated with a DMSO control, paclitaxel, cisplatin, cisplatin–paclitaxel, panobinostat and SAHA. They were then collected following primary treatment (denoted with the superscript “1”) and retreated with a subsequent treatment (denoted with the superscript “2”). Optical density was measured at 570 nm minus the background. (a) Caov-3 cells pretreated with panobinostat and SAHA demonstrated sustained chemosensitivity when retreated with classic chemotherapy (p < 0.001). (b) All Ovcar-3 cells were somewhat resensitized to chemotherapy after one treatment; however, panobinostat and SAHA were the most effective in reversing chemoresistance (p < 0.001) (n = 2).

Optical density of ovarian cancer cells following a second round of classic chemotherapy. Spheroids were pretreated with a DMSO control, paclitaxel, cisplatin, cisplatin–paclitaxel, panobinostat and SAHA. They were then collected following primary treatment (denoted with the superscript “1”) and retreated with a subsequent treatment (denoted with the superscript “2”). Optical density was measured at 570 nm minus the background. (a) Caov-3 cells pretreated with panobinostat and SAHA demonstrated sustained chemosensitivity when retreated with classic chemotherapy (p < 0.001). (b) All Ovcar-3 cells were somewhat resensitized to chemotherapy after one treatment; however, panobinostat and SAHA were the most effective in reversing chemoresistance (p < 0.001) (n = 2).