Table 4.
Results of the similarity search analysis a.
| Query Compounds | Number of Matches | Average MNK-1/2 Activity b | Average Similarity |
|---|---|---|---|
| Asn1051 | 45 | 1085.78 | 0.33 |
| Asn0225 | 30 | 1218.10 | 0.32 |
| Asn1125 | 14 | 646.57 | 0.32 |
| Asn2420 | 14 | 36.36 | 0.32 |
| Asn0240 | 12 | 608.00 | 0.32 |
| Asn2447 | 6 | 22.50 | 0.32 |
| Asn0252 | 4 | 2100.00 | 0.33 |
| Asn2416 | 3 | 35.00 | 0.32 |
| Asn2471 | 3 | 45.00 | 0.31 |
| Asn2459 | 2 | 36.50 | 0.31 |
| Asn2466 | 2 | 49.00 | 0.32 |
| Asn4780 | 2 | 1032.00 | 0.33 |
| Asn2422 | 1 | 46.00 | 0.31 |
| Asn2458 | 1 | 46.00 | 0.32 |
a All matches in the target dataset show a Tanimoto similarity value greater than 0.3 with the query compound. b In this calculation, if the inhibitory potential of a compound is expressed as < 100 nM, it was considered equal to 100 nM.