Figure 7.

Effect of TBR on training of 5xFAD mice in the MWM task. (A) For the 6-month-old mice there was a significant within groups difference across training days, but not a significant difference between groups. (B) There was a significant genotype effect by day 3 of testing in the 12-month-old mice, with WT+VEH mice taking less time to find the hidden platform in the MWM task than either the 5xFAD+VEH (p < 0.05) or 5xFAD+TBR mice, but by days 4 and 5, only the 5xFAD+VEH mice took significantly longer to find the platform. ** p < 0.05, between WT+VEH mice and both groups of 5xFAD mice; * p < 0.05, between WT+VEH and 5xFAD+VEH mice.