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Effect of TBR on latency to find the platform during the first trial of reversal testing in 5xFAD mice. TBR treatments reduced spatial learning deficits for both 6- and 12-month-old 5xFAD mice during the platform reversal trial 1 on the MWM task. There was not a significant difference between the 5xFAD+TBR mice and the WT+VEH or WT+TBR mice. ** p < 0.01, compared with all other groups. (∆, female mice; ●, male mice).
