Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 27;11(11):1423. doi: 10.3390/brainsci11111423

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

TBR treatment decreased pyknotic and tangle-like cells in the PFC and hippocampus of 5xFAD mice. (A) The 6- and 12-month-old 5xFAD and age-matched control mice were treated with (60 mg/kg BW) or vehicle for 2 months. (B) There was a significant difference in the number of pyknotic cells for 6- and 12-month-old mice in the PFC. (C) There was a significant difference in the number of pyknotic cells for 6- and 12-month-old mice in the CA1 area of the hippocampus. (D) In the CA3 area of the hippocampus there was a significant difference in the number of pyknotic cells for the 6-month-old animals but not for the 12-month-old mice. * p < 0.05.

TBR treatment decreased pyknotic and tangle-like cells in the PFC and hippocampus of 5xFAD mice. (A) The 6- and 12-month-old 5xFAD and age-matched control mice were treated with (60 mg/kg BW) or vehicle for 2 months. (B) There was a significant difference in the number of pyknotic cells for 6- and 12-month-old mice in the PFC. (C) There was a significant difference in the number of pyknotic cells for 6- and 12-month-old mice in the CA1 area of the hippocampus. (D) In the CA3 area of the hippocampus there was a significant difference in the number of pyknotic cells for the 6-month-old animals but not for the 12-month-old mice. * p < 0.05.