Figure 1.

(A) Schematic representation of the setting and exclusion criteria of the samples that were included in the present study. (B) Illustration of mechanical LA substrates that were used in the present study. A 44-year-old male without a history of regular alcohol consumption (upper panel) demonstrating a normal PR interval with a small LA size and preserved PALS; a 40-year-old male, ALDH2 polymorphism carrier with a history of chronic excessive alcohol consumption (>20 gday), showing a prolonged PR interval accompanied by LA remodeling and impaired PALS. (C) Distribution and daily alcohol intake (gday, median level, and IQR) across distinct ALDH2 genotypes as G/G, G/A, and A/A, rs671 (3 groups). One drink is equal to 12 gpure alcohol. Orange bars represent daily alcohol dose (g and green bars represent weekly alcohol drinks, respectively. Both were presented as median and IQR. * p < 0.05 vs. ALDH2 wild type (G/G), ^# p < 0.05 vs. ALDH2 polymorphism (G/A) via ANOVA.