Figure 2.

Linear regression models that were used in the present study, which demonstrate that ALDH2 polymorphism modified the association between daily alcohol intake (g/day) and worsened LA mechanical parameters (including LAVi (A), LAEF (B) and novel LA deformation markers (C–F) with steeper slopes for LAEF, PALS, and LA strain rates of the reservoir and booster pump functions (P_interaction: <0.05). The models were subjected to adjustment for age, body mass index, renal function in terms of eGFR (as continuous variables), gender, medical histories of hypertension, diabetes, coronary artery disease, medications used for hyperlipidemia, and active smoking status (in contrast to non-smokers plus prior smokers) (all as binary variables). Dashed lines refer to 95% confidence interval.