Figure 2.
Hydrocortisone increases energy expenditure and suppresses adiponectin expression in adipose tissue. (A) Administration of hydrocortisone increased oxygen (O2) consumption of wild type (WT) mice. The average O2 consumption was normalized to whole-body mass. Hydrocortisone treatment upregulated the expression of thermogenesis genes Ucp1 and Pparγ and downregulated the protein levels of adiponectin in iWAT (B) but not in BAT (C). (D) Hydrocortisone treatment decreased the levels of adiponectin in serum. White dots, vehicle group (n = 4); black dots, hydrocortisone group (n = 4). Hydro, hydrocortisone. The statistical data are presented as the mean ± S.E.M. * p < 0.05, *** p < 0.001.