Table 4.

Advantages and disadvantages of selective vs. nonselective inhibitors.

	Selective Inhibition	Non-Selective Inhibition
Advantages	▪Favorable toxicity profiles ▪Candidates for combination drug investigation ▪Easy determination of mechanism of action	▪Approval for multiple indications ▪Targeting of multiple dysregulated pathways ▪Less prone to resistance mechanisms
Disadvantages	▪Narrow scope of approved indications ▪Decreased ability to overcome resistance mechanisms	▪Wider toxicity profile ▪Less easily combined with other drugs due to unpredictable toxicity