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. 2021 Oct 21;11(11):1561. doi: 10.3390/biom11111561

Figure 7.

Figure 7

Disulfiram impairs clonogenic survival of LK17 cells. Neither disulfiram nor temozolomide radiosensitizes LK17 cells. (A–D). Dependence of normalized plating efficiency (A), vehicle-0 Gy control-normalized survival fraction (B), experimental arm-specific 0 Gy control-normalized survival fraction (C), and survival fraction after irradiation with 4 Gy (SF4 Gy, (D)) of LK17 cells on radiation dose (in (B,C)) and on cotreatment (in (A–D)) with vehicle (closed circles), disulfiram (DSF, 100 nM, open squares), temozolomide (TMZ, 30 µM, open triangles) and DSF + TMZ (open diamonds). Shown are means (±SE, n = 12) and additionally individual values in (A,D). Mean (±SE, n = 12) absolute plating efficiency of 0 Gy/vehicle-treated LK17 cells was 0.75 ± 0.09. **, *** and n.s. indicate p ≤ 0.01, p ≤ 0.001, and not significantly differing, respectively, as calculated by nonparametric Kruskal–Wallis with Dunn’s multiple comparison test.