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. 2021 Nov 8;9(11):1642. doi: 10.3390/biomedicines9111642

Figure 1.

Figure 1

Biogenesis and diversity of circRNAs. CircRNAs are produced by exon-skipping or another non-canonical event (like back-splicing) that can initiate internal splicing. CircRNAs are present in blood, body fluids and tissues, and can serve as potential disease biomarkers. They are non-polyadenylated, unlike mRNAs, and they are covalently closed. CircRNAs are resistant to exonucleases digestion due to their lack of 5′ or 3′ end. CircRNAs can be exonic, intronic or a combination of both (this illustration was created with BioRender.com, accessed on 3 November 2021).