Scheme 4.
Synthetic procedure for (S)- or (R)-Fmoc-β3-isoAsp(NHPr)-OH. Reagents and conditions: (i) n-propylamine, EDC.HCl/HOBt/TEA, DCM/DMF, rt, 3 h; (ii) TFA/DCM (1:1), rt, 1 h.
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