Table 1.
The different TLRs found in humans and mice, and the ligands that activate those TLRs (TLR10 is not functional in mice, while TLR11 is not detected in humans).
| TLR | CD | Ligand | Pathogen Recognised | Localisation |
|---|---|---|---|---|
| TLR1 | CD281 | Tri-acyl lipopeptides | Gram-positive bacteria | Extracellular |
| TLR2 | CD282 | Di- and tri-acyl Lipopeptides | Gram-positive bacteria; plasmodium | Extracellular |
| TLR3 | CD283 | dsRNA | dsRNA viruses | Endosomal |
| TLR4 | CD284 | Lipopolysaccharide | Gram-negative bacteria | Extracellular |
| TLR5 | CD285 | Flagellin | Motile bacteria | Extracellular |
| TLR6 | CD286 | Di-acyl lipopeptides | Gram-positive bacteria | Extracellular |
| TLR7 | CD287 | ssRNA | ssRNA viruses | Endosomal |
| TLR8 | CD288 | ssRNA; GC rich RNA | ssRNA viruses | Endosomal |
| TLR9 | CD289 | CpG DNA | DNA viruses; viral and bacterial DNA | Endosomal |
| TLR10 | CD290 | Unknown | - | Extracellular |