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Prevalence of HPV and p16 in HNSCC. (A) Genotype prevalence in HNSCC. Cases found with each genotype are shown as single infection (SI) and multiple infections (MI); (B) distribution of most frequent high-risk genotypes per anatomical site; (C) prevalence of HNSCC according to HPV presence and p16 expression; (D) prevalence of HPV and p16 expression per anatomical site. Concordance in OPSCC was k = 0.75, in OCSS k = 0.36 and in LSCC k = 0.54, significance 0.000.
