Table 1.
Clinic characteristics of head and neck cancer patients, DNA HPV presence, and p16 expression.
| Characteristics | Total | HPV+ | P16+ | |||
|---|---|---|---|---|---|---|
| % | n = 414 | % | n = 368 | % | n = 412 | |
| Age | ||||||
| ≤55 | 24.1 | 88 | 35.4 | 29 | 38.6 | 34 |
| 56–75 | 53.7 | 196 | 20.1 | 35 | 33.8 | 66 |
| ≥76 | 22.2 | 81 | 12.5 | 9 | 21.3 | 17 |
| p = 0.002 | p = 0.043 | |||||
| Gender | ||||||
| Men | 71.3 | 286 | 22.5 | 57 | 32.7 | 93 |
| Woman | 28.7 | 115 | 22.5 | 23 | 31.3 | 36 |
| Anatomic site | ||||||
| Larynx | 39.1 | 162 | 18.2 | 25 | 30.4 | 49 |
| Oropharynx | 19.6 | 81 | 40.5 | 30 | 54.3 | 44 |
| Oral cavity | 41.3 | 171 | 17.2 | 27 | 23.5 | 40 |
| p = 0.000 | p = 0.000 | |||||
| Stage | ||||||
| I–II | 36.5 | 91 | 15.6 | 14 | 18.7 | 17 |
| III–IV | 63.5 | 158 | 20.1 | 30 | 32.3 | 51 |
| p = 0.26 | ||||||
| Histological Grade | ||||||
| I | 22.2 | 75 | 18.5 | 12 | 34.7 | 26 |
| II | 66.6 | 225 | 17.3 | 35 | 25.0 | 56 |
| III | 11.2 | 38 | 24.2 | 8 | 36.8 | 14 |
| Smoke | ||||||
| Yes | 64.4 | 125 | 18.9 | 23 | 30.4 | 38 |
| No | 35.6 | 69 | 23.8 | 15 | 37.7 | 26 |
| Alcohol | ||||||
| Yes | 61.5 | 112 | 19.1 | 21 | 30.4 | 34 |
| No | 38.5 | 70 | 14.3 | 9 | 31.4 | 22 |
HPV was evaluated in 368 cases and p16 in 412. The concordance between HPV and p16 was Kappa 0.55 p = 0.000.