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. 2021 Oct 21;10(11):2828. doi: 10.3390/cells10112828

Figure 3.

Figure 3

Preeclampsia is characterized by intense oxidative stress, inflammation, and endothelial dysfunction. The activation of NLRP3 may start with the production of ROS. Inflammasome activation is responsible for the release of inflammatory agents during the immune response, such as IL-1β and IL-18. High levels of ROS increase NO catabolism and decrease NO bioavailability as well as increasing factors such as sFlt-1 and sEng. This process enhanced inflammation-related genes expression, contributing to endothelial dysfunction.