Figure 3.

Melanoma microenvironment. The main cellular and non-cellular components present in the melanoma microenvironment are illustrated and indicated in the right part of the figure. The interactions among all of them are reported with an arrow and are described in more detail with a letter indicating: (a) melanoma autocrine growth stimulation and cell survival; (b) melanoma ECM remodeling; (c) stromal reprogramming; (d) regulation of inflammation; (e) leucocyte recruitment; (f) tumor angiogenesis; (g) tumor metabolic reprogramming.