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. 2021 Nov 5;10(11):3031. doi: 10.3390/cells10113031

Table 1.

NAD+ -dependent deacetylases Sirtuins.

Sirtuin Localization Activity Reference
SIRT1 Cytosol, nucleus deacetylase [88]
SIRT2 Cytosol deacetylase [89]
SIRT3 Mitochondria deacetylase [90]
SIRT4 Mitochondria ADP-ribosyl transferase [85]
SIRT5 Mitochondria desuccinylase [91]
SIRT6 nucleus ADP-ribosyl transferase [92]
SIRT7 nucleus deacetylase [93]