Figure 2.

(A) Images and treatment timeline of patient #505 treated with tylectomy for refractory tumor who achieved good visual outcome. The patient was diagnosed with unilateral Group D retinoblastoma in the right eye at 2 years of age. Following 6 cycles of systemic chemotherapy, there was still a significant active tumor inferior to the optic disc and vitreous seedings. A tylectomy was performed to remove all active tumors inside the eye. One cycle of adjuvant systemic chemotherapy was given 2 days following tylectomy. There was no tumor recurrence at 70-month follow-up with visual acuity tested 20/100. IVC, intravenous chemotherapy; Ivitc, intravitreal chemotherapy. (B) Images and treatment timeline of patient #607 treated with tylectomy for refractory tumor who developed anterior chamber tumor recurrence. The patient was diagnosed with unilateral Group D retinoblastoma in the left eye at 2 years of age. Following 3 cycles of systemic chemotherapy, there was a persistent large active tumor in the temporal retina, diffuse subretinal seedings, and serous retinal detachment. The parents declined enucleation. A tylectomy was performed to remove all active tumors inside the eye. Five months following tylectomy, the eye developed anterior chamber tumor recurrence. The eye was enucleated and had pT3a histopathology. The child received 4 cycles of systemic chemotherapy. There was no evidence of orbital recurrence at 67 months follow-up. IVC, intravenous chemotherapy; Enu, enucleation; AC, anterior chamber.